A pregnancy-associated serum protein of the mouse (α1-PAP) has recently been reported to be also synthesized by the non-pregnant female, but not the untreated male, in response to injury. The role of gonadal hormones in this phenomenon has been investigated. Ovariectomy abolished the ability of injury to induce synthesis of α1-PAP. Although administration to ovariectomized animals of oestradiol alone resulted in the appearance of low concentrations of α1-PAP after injury, injection of either progesterone or oestradiol plus progesterone permitted injury to induce concentrations of α1-PAP similar to those observed in intact injured females. Castrated mice, like intact males, failed to produce α1-PAP in response to injury, but administration of either oestradiol or oestradiol plus progesterone caused injury to induce concentrations of α1-PAP similar to those in injured intact females. Administration of testosterone to intact females abolished the α1-PAP response to injury and administration of oestradiol plus progesterone to intact males failed to induce the same response as in castrated males. These findings suggest that testosterone can inhibit the synthesis of α1-PAP in response to injury in both sexes whereas oestradiol and progesterone exhibit different abilities in males and females to facilitate the induction of α1-PAP synthesis by injury.
J. Endocr. (1984) 101, 315–318
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 0 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
