Hyperprolactinaemia was induced in castrated, testosterone-treated male rats using ectopic pituitary grafts under the kidney capsules. After 6 weeks the absolute refractory period of stria terminalis neurones in these animals did not differ significantly from long-term castrated rats (mean = 1·72 vs 1·69 ms) in spite of the presence of normal testosterone concentrations. Gonadally intact animals, and sham-operated castrated animals treated with testosterone, showed by comparison the characteristic significantly shorter absolute refractory period normally associated with testosterone stimulation (mean = 1·15 and 1·08 respectively). These results provide the first demonstration that hyperprolactinaemia can abolish central sensitivity to testosterone.
J. Endocr. (1984) 102, 109–113
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