9α-Fluorocortisol has been postulated to have 'hypertensinogenic' as well as 'mineralocorticoid' and 'glucocorticoid' activity. The present study examined the blood pressure and metabolic effect in sheep of the structurally related steroids 9α-fluorodeoxycorticosterone (9α-FDOC) and 9α-fluorocorticosterone (9α-FB). Infusions of these fluorinated steroids at 0·63 and 0·67 mg/day respectively for 5 days produced falls in plasma potassium, but only 9α-FB increased urine volume. 9α-FDOC raised mean arterial pressure by 11 mmHg and 9α-FB raised it by 14 mmHg. Addition of a 9α-fluoro group appears to increase both 'mineralocorticoid' and 'hypertensinogenic' steroid potencies.
J. Endocr. (1985) 104, 291–294
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