Effect of anterior hypothalamic deafferentation and continuous growth hormone infusion on the hepatic synthesis of α2u-globulin in the male rat

in Journal of Endocrinology
Authors:
B. Chatterjee
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W. F. Demyan
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J.-Å. Gustafsson
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M. W. Harris
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T. Hökfelt
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G. Norstedt
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A. K. Roy
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ABSTRACT

Anterior hypothalamic deafferentation and infusion of human GH (hGH) in the normal male rat caused a marked reduction in the hepatic concentration of α2u-globulin, an androgen-dependent protein. Although s.c. injections of hGH (twice-daily) resulted in more than a 50% reduction in the hepatic level of α2u-globulin, the same dose of hGH when administered continuously through osmotic minipumps caused a threefold greater inhibition. The decreased hepatic concentration of α2u-globulin after hGH administration was associated with corresponding changes in the hepatic level of translatable α2u-globulin messenger RNA. Continuous infusion of hGH through osmotic minipumps and removal of the anterior hypothalamic influence on GH secretion by deafferentation also caused a marked reduction in the cytoplasmic androgen-binding activity of the rat liver. These results suggest that alterations in the level and pattern of GH secretion may influence hepatic androgen-binding activity and α2u-globulin synthesis.

J. Endocr. (1986) 108, 351–355

 

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