Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London w12 0hs
received 30 December 1985
Banting & Best (1922) used what is now a classical endocrinological technique in their discovery of insulin. They pulverized pancreas with buffer, filtered the crude tissue extract and found that it produced hypoglycaemia when injected into an experimental dog. One would have thought that within a few years most bodily tissues would have been treated similarly in a search for further circulating hormones. This has not been the case. As recently as 1981 de Bold and his colleagues prepared an extract of rat cardiac atria in a fashion not dissimilar to that of Banting & Best (1922) and found that injection into a donor rat produced a dramatic diuresis and natriuresis. Indeed the urine flow increased tenfold whilst sodium and chloride excretion increased more than 30-fold (de Bold, Borenstein, Veress &
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