The tumorigenic virus avian erythroblastosis virus, which causes erythroleukaemias and sarcomas in chickens, encodes two oncogenes v-erb A and v-erb B that are both structurally related to receptors for hormones. V-erb B is essential for cell transformation and resembles a truncated form of the receptor for epidermal growth factor (Downward, Yarden, Mayes et al. 1984) whereas v-erb A, which arrests cell differentiation and enhances the effect of v-erb B (Kahn, Frykberg, Brady et al. 1986), shares homology with steroid hormone receptors (Weinberger, Hollenberg, Rosenfeld & Evans, 1985; Green, Walter, Kumer et al. 1986; Greene, Gilna, Waterfield et al. 1986; Krust, Green, Argos et al. 1986).
The structural and functional analysis of steroid hormone receptors has provided clues as to the potential functional role of v-erb A in tumorigenesis. Two functional domains have been defined within all classes of steroid hormone receptor. One domain is responsible for steroid binding. It is
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