1. Daily treatment of monkeys (Macaca mulatta) with 25 or 30 mg ACTH in beeswax/arachis oil almost doubles the size and alters the histological appearance of the adrenal glands. The life-span of skin homografts is, however, only prolonged by a trivial amount.
2. Since 15 mg cortisone daily has an equally trivial effect it may be that the ineffectiveness of treatment with ACTH depends as much on relative insensitivity of the reactive tissues to cortisone as on the character of the hormones produced by the adrenal gland.
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