Responses of hypothalamic and pituitary mRNA to physical and psychological stress in the rat

in Journal of Endocrinology
Restricted access

ABSTRACT

In-situ hybridization histochemistry was used to measure corticotrophin-releasing factor mRNA and proenkephalin A mRNA in the paraventricular nucleus (PVN), and pro-opiomelanocortin (POMC) mRNA in the anterior pituitary of the rat. Levels of message were determined at 1, 2, 4 and 8 h after exposure to a variety of physical and psychological stresses. Corticotrophin-releasing factor mRNA in the PVN and POMC mRNA in the anterior pituitary increased in response to i.p. hypertonic saline, restraint and swim stress but not to cold stress. Proenkephalin A mRNA was raised only in response to the physical stress of i.p. injection of hypertonic saline. These results suggest that different afferent pathways and hypothalamic neurotransmitters may be involved in mediating the hypothalamic response to different physical and psychological stresses.

Journal of Endocrinology (1989) 122, 705–711

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 512 353 4
Full Text Views 181 10 0
PDF Downloads 297 18 0