Paracrine control of anterior pituitary hormone secretion

in Journal of Endocrinology
Authors:
T. H. Jones
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B. L. Brown
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P. R. M. Dobson
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Introduction

Intercellular communication is effected through the release and action of substances known as paracrine agents. Recent studies are providing increasing evidence that pituitary hormone secretion is under the control of paracrine as well as hypothalamic factors. The individual cell types within the rat anterior pituitary gland appear to be arranged in specific groups and juxtapositions, and this precise organization of cells provides an anatomical basis for an intercellular control system in the pituitary gland. There is good circumstantial evidence for a variety of paracrine interactions within the anterior pituitary gland, although the exact physiological functions of different proposed paracrine agents have yet to be fully elucidated. Many substances have been shown to affect the release of each of the pituitary hormones directly, and there is evidence that some of these are synthesized and released within the anterior pituitary and may therefore act as paracrine agents. Established and

 

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