The role of endothelin in the control of adrenocortical function: stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells

in Journal of Endocrinology
Authors:
J. P. Hinson
Search for other papers by J. P. Hinson in
Current site
Google Scholar
PubMed
Close
,
G. P. Vinson
Search for other papers by G. P. Vinson in
Current site
Google Scholar
PubMed
Close
,
S. Kapas
Search for other papers by S. Kapas in
Current site
Google Scholar
PubMed
Close
, and
R. Teja
Search for other papers by R. Teja in
Current site
Google Scholar
PubMed
Close
Restricted access
Rent on DeepDyve

Sign up for journal news

ABSTRACT

The rate of blood flow through the intact adrenal gland is closely linked to steroid hormone secretion, and although the mechanism involved is unknown, it is thought to involve secretory products of the vascular endothelium.

In dispersed cell preparations, endothelin-1 and -3 both caused a dose-dependent and highly sensitive increase in steroid secretion by zona glomerulosa and zona fasciculata cells of the rat and human adrenal cortex. In addition, when the perfused rat adrenal was stimulated with ACTH, significant increases in steroid secretion and perfusion medium flow rate were accompanied by significantly increased secretion of immunoreactive endothelin into the adrenal vein. It is proposed that endothelin has a role in mediating the adrenocortical response to ACTH stimulation.

Journal of Endocrinology (1991) 128, 275–280

 

  • Collapse
  • Expand