The recovery of urinary pregnanediol after the injection of progesterone was studied in seventeen women and four men.
In non-pregnant subjects less than 20% of the injected progesterone was recovered as urinary pregnanediol. The recovery did not increase significantly when progesterone was given to pregnant women, to women in the luteal phase of the cycle or after prolonged administration to postmenopausal women. The 'progesterone priming' effect described by Sommerville & Marrian [1950] was not observed.
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