Rats maintained on a low-iodine diet for 2 years grew fairly normally, but showed thyroid hyperplasia and colloid depletion.
Radio-iodine was taken up rapidly to a high level and equally rapidly discharged.
There was wide variation in the size of the thyroids, but great uniformity in the histological pattern and manner of utilizing radio-iodine.
Nodules appeared in the thyroid from the 5th month in increasing numbers. They were of a trabecular type, and autoradiographically their iodine uptake was, as a rule, similar to that of the rest of the gland.
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