If the knowledge accumulated in the past 4 years on the reproductive role of interferon-α (IFN-α) had been available 20 years ago, then there is no doubt that this molecule would have been designated as a reproductive hormone. Eventually some workers would have expressed surprise that the molecule also exhibited properties of a lymphokine, though it might well have been argued that the findings were the result of contamination in 'pure' preparations of the hormone. But the surprise has been in the opposite direction: a material which is considered as an archetypal lymphokine has been very belatedly identified as a major embryonic signal in several mammalian species. The extent of this 'surprise' may be judged from a recent review in this Journal which described (with admirable clarity and detail) the possible role of lymphokines in endocrinology but made no mention of the fact that endocrinology has just hijacked the most
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