Manipulation of inhibin during the luteal-follicular phase transition of the primate menstrual cycle fails to affect FSH secretion

in Journal of Endocrinology
Authors:
H M Fraser
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C G Tsonis
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DOI:
https://doi.org/10.1677/joe.0.1420181
Volume/Issue:
Volume 142: Issue 1
Article Type:
Research Article
Page Range:
181–186
Online Publication Date:
Jul 1994
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Abstract

The pattern of inhibin concentrations in blood during the menstrual cycle in primates has suggested an endocrine role of inhibin in the negative feedback control of FSH secretion during the luteal phase. Conversely, the fall in inhibin during the late luteal phase may play a role in the rise in serum FSH during the luteal-follicular phase transition. This hypothesis was examined by determining the effects of manipulation of inhibin on FSH secretion in stumptailed macaques. During the mid-luteal phase the putative inhibin feedback was inhibited by i.v. administration of 20 ml of ovine antiserum to human recombinant inhibin in 4 macaques. FSH secretion was unaffected during the initial 24 h period post-treatment and the timing of the rise in FSH which occurred during the subsequent luteal-follicular phase transition was normal. To determine whether the elevated serum concentrations of FSH observed during the early follicular phase could be reduced by administration of inhibin, 5 cyclic macaques were treated with 200 μg of recombinant human inhibin i.v. Serum FSH concentrations were unaltered. These results suggest that inhibin does not play a major role in modulating FSH secretion during the luteal-follicular phase transition.

Journal of Endocrinology (1994) 142, 181–186

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
6
Article Type:
Research Article
Print Publication Date:
01 Jan 1994
Online Publication Date:
Jul 1994