While the effects of cytokines on the hypothalamo-pituitary-adrenal axis have received a great deal of attention in recent years the effects of cytokines on posterior pituitary hormone release has been less well characterized. In the present study we have investigated the effects of a single i.p. injection of interleukin (IL)-1β on circulating levels of vasopressin (AVP) in the rat. We have found that the ability of IL-1β to increase plasma AVP is strongly influenced by circulating levels of glucocorticoid steroids. IL-1β did not affect plasma AVP in sham-operated control animals over the 4 h period of study. In contrast, following adrenalectomy we were able to stimulate AVP substantially with increases over the 4 h period. This effect was reduced by treatment of adrenalectomized rats with a low dose of dexamethasone and abolished with a high dose. These data suggest an inverse relationship between circulating levels of glucocorticoids and the ability of IL-1β to stimulate plasma AVP.
Journal of Endocrinology (1994) 142, 361–366
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
Sept 2018 onwards | Past Year | Past 30 Days | |
---|---|---|---|
Full Text Views | 0 | 0 | 0 |
PDF Downloads | 3 | 1 | 0 |