1. Adrenalectomy in the mouse causes a decrease in its resistance to the effects of cold; this resistance can be completely restored by the administration of cortisone acetate and other 11-oxygenated corticosteroids. A linear relationship exists between the survival time of adrenalectomized mice exposed to cold and the logarithm of the dose of cortisone acetate or other corticosteroids injected.
2. The assay depending upon the resistance of mice to cold is simple and easier to perform than assays using either the response of the eosinophils or of liver glycogen in mice. The sensitivity of the method is less than that of the latter assays. Its precision is less than that of the glycogen assay, but is of the same order as that of the eosinophil assay. Compared with the similar assay using rats it is cheaper to perform, requires less time and has a similar order of precision and sensitivity.
3. The assay depending upon the resistance of mice to cold provides a simple and rapid means of screening compounds for adrenocortical activity.
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