THE PREVENTIVE EFFECT OF GLUCAGON (HGF) AGAINST THE DIABETOGENIC ACTION OF ALLOXAN AND ITS ANTAGONISM BY INSULIN

in Journal of Endocrinology
View More View Less
Restricted access

SUMMARY

The intravenous injection of glucagon (0·4 mg/kg) 12–30 min before the administration of a diabetogenic dose of alloxan (60 mg/kg) prevents the development of alloxan diabetes in dogs.

The protection obtained with glucagon is abolished by a subcutaneous injection of insulin (2 i.u./kg) administered 2 hr previously.

The possible mechanism of this protection and of its antagonism by insulin is discussed.

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 69 29 1
Full Text Views 32 0 0
PDF Downloads 32 0 0