Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep

in Journal of Endocrinology
Authors:
P A Martin
Search for other papers by P A Martin in
Current site
Google Scholar
PubMed Close
and
A Faulkner
Search for other papers by A Faulkner in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1677/joe.0.1510107
Volume/Issue:
Volume 151: Issue 1
Article Type:
Research Article
Page Range:
107–112
Online Publication Date:
Oct 1996
Restricted access
Rent on DeepDyve

Sign up for journal news

Abstract

The effects of intravenous somatostatin-28 (S28) infusion on glucose-stimulated and glucagon-like peptide-1(7–36)amide (GLP-1)-augmented insulin secretion were studied in sheep. S28 was infused via a jugular catheter for 15 min at a rate of 1·1 pmol/kg/min either alone or together with GLP-1 and/or glucose. S28 infusion did not significantly lower circulating basal insulin concentrations in fed sheep. Glucose-stimulated insulin secretion was significantly inhibited by S28 infusion, serum concentrations decreasing from about 200 to 150 pmol/l. GLP-1 significantly augmented glucose-stimulated insulin secretion, serum concentrations increasing from about 230 to 280 pmol/l. S28 completely counteracted this effect of GLP-1. S28 infusion also significantly decreased the circulating concentrations of glucose-dependent insulinotrophic polypeptide (GIP) and GLP-1 in fed sheep (from about 110 to 45 pmol/l for GIP and from about 25 to 15 pmol/l for GLP-1). The physiological implications of these observations are discussed with particular reference to the ruminant. It is concluded that S28 may have an important endocrine role in the control of insulin secretion and regulation of nutrient partitioning.

Journal of Endocrinology (1996) 151, 107–112

Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 3 0 0
PDF Downloads 3 1 0

 

  • Collapse
  • Expand
Print ISSN:
0022-0795
Online ISSN:
1479-6805
Page(s):
6
Article Type:
Research Article
Print Publication Date:
01 Jan 1996
Online Publication Date:
Oct 1996