A growing body of evidence indicates that growth hormone (GH) is important in maintaining cardiovascular health in adults. This evidence falls into three main categories: results indicating that GH deficiency (GHD) in adults may be associated with detrimental cardiovascular abnormalities; results indicating that some of these abnormalities can be rectified with GH replacement therapy; and results indicating that GH therapy can have beneficial effects in normal (i.e. non-GH-deficient) adults with cardiovascular disease.
GHD in adults has been shown to be associated with impairment of cardiac function and increases in the prevalence of a number of well-known risk factors for cardiovascular disease.
Impairment of cardiac function tends to be more marked in adults who have had GHD since childhood than in those who have acquired it post-pubertally. In the former group, cardiac output has been found to be significantly reduced both at
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Online ISSN: 1479-6805
Print ISSN: 0022-0795
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