The urinary excretion of oestrone, oestradiol, oestriol and 5β-pregnane-3α:20α-diol has been determined by chemical methods during four menstrual cycles. Vaginal smears were also obtained throughout the cycles, and the degree of cornification of the vaginal epithelium has been compared with oestrogen and pregnanediol excretion.
Of the four cycles studied, only one had a cornification curve which could definitely be described as of the normal ovulatory type. The steroid excretion patterns, however, conformed to those expected in an ovulatory cycle, except in one instance where an abnormal excretion of oestradiol was found during the follicular phase.
The correlation coefficient for oestrogens and the percentage of cornified cells in the smear has been calculated for the separate cycles and for the four cycles added together. The degree of correlation varied between subjects and between different cycles in the same subject.
The implications of the results are discussed.
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Online ISSN: 1479-6805
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