Homografts of skin exchanged between two strains of rat survive for an average of 8·8 days.
Survival time is increased to 14·1 days by the daily administration (beginning on the day following operation) of 4·0 mg cortisol, but 2 i.u. ACTH (Cortrophin 'Z') daily has no effect (survival time = 9·0 days).
If, however, treatment with ACTH is begun 28 days before operation the homografts survive for 17 days (Cortrophin 'Z') and for 11·4 days (Acthar gel).
The normal processes of wound repair are slowed down in proportion to the influence of treatment on the immunity reaction.
The results conform to the view that prolonged treatment with ACTH alters the ratio of cortisol/corticosterone secreted by the adrenal cortex.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 1 | 1 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
