THE EFFECT OF 6-DIAZO-5-OXO-l-NORLEUCINE (DON) ON PREGNANCY

in Journal of Endocrinology
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SUMMARY

Intraperitoneal and intra-amniotic administration of 6-diazo-5-oxo-l-norleucine (DON) will interrupt pregnancy in mice at all stages of gestation with doses which are only a small fraction of the LD50 for this compound. The intra-amniotic injection of DON into pregnant rabbits kills the foetus but leaves the placenta intact. Rabbits are relatively resistant to the toxic action of this compound. The available evidence indicates that DON acts directly on the developing embryo.

 

      Society for Endocrinology

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