1. The effect of the administration of adrenocorticotrophic hormone (ACTH) before and after adrenalectomy on the excretion of oestrone, oestradiol-17β and oestriol in the urine has been studied in twelve patients with recurrent or metastatic breast cancer.
2. When the adrenals were intact the intravenous infusion of ACTH for 48 hr produced a three- to ninefold increase in the output of urinary oestrogens. Adrenalectomy completely abolished this response.
3. Adrenalectomy reduced the excretion of oestrogens.
4. There was no apparent correlation between the response of the disease to adrenalectomy and the output of urinary oestrogens.
5. These findings are discussed with particular regard to the limitations of the assay method employed.
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 0 | 0 | 0 |
| PDF Downloads | 3 | 1 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
