THE FATE OF INJECTED OXYTOCIN IN THE RABBIT

in Journal of Endocrinology
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SUMMARY

Oxytocin injected intravenously into anaesthetized rabbits disappears rapidly from the blood stream, and its disappearance is retarded in animals whose liver or kidneys have been excluded from the circulation. The rate of disappearance of injected vasopressin is similar to that of oxytocin in intact rabbits. Homogenates of rabbit liver and kidney inactivate oxytocin rapidly in vitro; the site of inactivation by the kidney is in the tubules and not in the glomeruli.

 

      Society for Endocrinology

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