A single intravenous injection of reserpine (1 mg/kg), given either on day 15 of pseudopregnancy or after priming with 0·2 mg oestradiol-17β daily for 10 days, resulted in lactogenesis in virgin female rabbits of the New Zealand White breed. This finding is in contrast to earlier negative results with Dutch rabbits in this laboratory. Thymus weight dropped significantly after reserpine in the pseudopregnant animals, but reserpine did not lower the thymus weight in oestradiol-primed rabbits to an extent greater than could be accounted for by the effect of the oestrogen alone.
From these results, it is concluded that there is a breed difference in the lactogenic response of New Zealand White and Dutch rabbits to reserpine.
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