The effect of relaxin on the thyroid weights of intact, oophorectomized and hypophysectomized female Sprague-Dawley rats, intact and castrated male rats, and male and female guinea-pigs has been described.
Relaxin caused significant increases in thyroid weights in the presence of oestrogen or the ovaries and an intact pituitary. This effect of relaxin on the thyroid was not found to be significant in the presence of the testes or testosterone.
Evidence is presented that the response observed in the thyroid was due to relaxin and not to a contaminant of the relaxin extract.
A theory of action is described.
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Online ISSN: 1479-6805
Print ISSN: 0022-0795
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