The administration of 5-hydroxytryptamine (5-HT) to immature female mice inhibts the development of sexual maturity, as shown by opening of the vagina and the occurrence of vaginal oestrus. The weight of the sex organs of treated animals is well below that of controls. There is little or no effect on body growth. Given to mature female mice, the drug depresses the weight of the sex organs. These effects are not due to decreased sensitivity of the gonads to gonadotrophin, or of the uterus and vagina to oestrogen. Similar effects have been obtained with iproniazid and other amine oxidase inhibitors, all hydrazides. Iproniazid produced a marked increase in the weight of the spleen with deposits of pigment giving a positive Prussian blue reaction.
5-HT and iproniazid produced much less striking effects when given to immature male mice; there was with both drugs a significant increase in the weight of the adrenals.
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