1. Rat kidney slices inactivated 8-arginine vasopressin 1·23 times as fast as 8-lysine vasopressin and 2·14 times as fast as 2-phenylalanine-8-lysine vasopressin. The rate of inactivation became dependent upon the initial concentration of these peptides when this reached 8–11 μg./ml. There was a positive correlation between the apparent first-order rate constants of these vasopressins and their pressor potency per mg. peptide.
2. 8-Arginine vasopressin was not inactivated by hyaluronidase but rat kidney slices inactivated 8-arginine vasopressin 1·25 times as fast when testicular hyaluronidase was present.
3. Slices of rat kidney taken 7 days after bilateral adrenalectomy inactivated 8-arginine vasopressin at the same rate as those taken from normal animals. Cortisol sodium succinate did not affect the rate of 8-arginine vasopressin inactivation by normal rat kidney slices, but there was no increased rate of inactivation when hyaluronidase, 8-arginine vasopressin and cortisol sodium succinate were incubated together with normal rat kidney slices.
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