The therapeutic effect of interleukin-22 in high androgen-induced polycystic ovary syndrome

in Journal of Endocrinology
View More View Less
  • 1 Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China
  • 2 Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, School of Basic Medical Sciences, Peking University, Beijing, China
  • 3 Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China
  • 4 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China
  • 5 National Clinical Research Center for Obstetrics and Gynecology, Beijing, China
  • 6 Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest, Beijing, China

Correspondence should be addressed to Y Pang: yanlipang@bjmu.edu.cn
Restricted access

Polycystic ovary syndrome (PCOS) is a complex syndrome involving both endocrine and metabolic disorders. Gut microbiota and the intestinal immune factor IL-22 play an important role in the pathogenesis of PCOS. However, the therapeutic role of IL-22 in high androgen-induced PCOS mice is not clear. We aimed to determine the therapeutic effects of IL-22 on the DHEA-induced PCOS mouse model and to explore the possible mechanism of IL-22 in regulating hyperandrogenism-associated PCOS. Insulin resistance levels and ovarian functions were investigated in DHEA-induced PCOS mice with or without additional IL-22 treatment. We found that IL-22 could reverse insulin resistance, disturbed estrous cycle, abnormal ovary morphology, and decreased embryo number in DHEA mice. Mechanistically, IL-22 upregulated the browning of white adipose tissue in DHEA mice. This study demonstrated that IL-22-associated browning of white adipose tissue regulated insulin sensitivity and ovarian functions in PCOS, suggesting that IL-22 may be of value for the treatment of PCOS with a hyperandrogenism phenotype.

Supplementary Materials

    • Supplementary Table 1. Primer sequences for real-time PCR used in the study.

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 2340 2340 203
Full Text Views 144 144 19
PDF Downloads 85 85 23