Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

in Journal of Endocrinology
Authors:
Sisi Luan Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

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Wenkai Bi Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

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Shulong Shi Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China

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Li Peng Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

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Zhanbin Li Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

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Jie Jiang Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China

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Ling Gao Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China

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Yifeng Du Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China

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Xu Hou Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
Stem Cell Research Center, Shandong Provincial Hospital affiliated to First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

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Zhao He Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

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Jiajun Zhao Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

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Correspondence should be addressed to X Hou or Z He or J Zhao: 15153285655@163.com or zhaohe7711@qq.com or jjzhao@sdu.edu.cn
DOI:
https://doi.org/10.1530/JOE-20-0026
Volume/Issue:
Volume 246: Issue 1
Article Type:
Research Article
Page Range:
41–55
Online Publication Date:
Jul 2020
Copyright:
© 2020 Society for Endocrinology 2020
Restricted access
Rent on DeepDyve

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Subclinical hyperthyroidism, a condition characterized by decreased thyroid-stimulating hormone (TSH) and normal concentration of thyroid hormone, is associated with an elevated risk for cognitive impairment. TSH is the major endogenous ligand of the TSH receptor (TSHR) and its role is dependent on signal transduction of TSHR. It has not, however, been established whether TSHR signaling is involved in the regulation of cognition. Here, we utilized Tshr knockout mice and found that Tshr deletion led to significantly compromised performance in learning and memory tests. Reduced dendritic spine density and excitatory synaptic density as well as altered synaptic structure in CA1 subfield of the hippocampus were also noted. Furthermore, the synapse-related gene expression was altered in the hippocampus of Tshr -/- mice. These findings suggest that TSHR signaling deficiency impairs spatial learning and memory, which discloses a novel role of TSHR signaling in brain function.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© 2020 Society for Endocrinology 2020
Page(s):
15
Article Type:
Research Article
Received Date:
03 Apr 2020
Accepted Date:
21 Apr 2020
Print Publication Date:
01 Jul 2020
Online Publication Date:
Jul 2020
Keywords:
TSHR; cognitive function; hippocampus; learning and memory

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