Thyrotropin receptor signaling deficiency impairs spatial learning and memory in mice

in Journal of Endocrinology
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  • 1 Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
  • 2 Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, China
  • 3 Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China
  • 4 Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
  • 5 Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, China
  • 6 Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China
  • 7 Stem Cell Research Center, Shandong Provincial Hospital affiliated to First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China

Correspondence should be addressed to X Hou or Z He or J Zhao: 15153285655@163.com or zhaohe7711@qq.com or jjzhao@sdu.edu.cn
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Subclinical hyperthyroidism, a condition characterized by decreased thyroid-stimulating hormone (TSH) and normal concentration of thyroid hormone, is associated with an elevated risk for cognitive impairment. TSH is the major endogenous ligand of the TSH receptor (TSHR) and its role is dependent on signal transduction of TSHR. It has not, however, been established whether TSHR signaling is involved in the regulation of cognition. Here, we utilized Tshr knockout mice and found that Tshr deletion led to significantly compromised performance in learning and memory tests. Reduced dendritic spine density and excitatory synaptic density as well as altered synaptic structure in CA1 subfield of the hippocampus were also noted. Furthermore, the synapse-related gene expression was altered in the hippocampus of Tshr -/- mice. These findings suggest that TSHR signaling deficiency impairs spatial learning and memory, which discloses a novel role of TSHR signaling in brain function.

 

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