Maternal adaptations of pancreatic islets and glucose metabolism after lactation

in Journal of Endocrinology
Authors:
Gustavo Canul-Medina Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, Mexico

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Leticia Riverón-Negrete Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, Mexico

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Karina Pastén-Hidalgo Cátedra CONACYT, Instituto Nacional de Pediatría, Mexico City, Mexico

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Paulina Morales-Castillo Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, Mexico

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Francisco García-Vázquez Laboratorio de Immunología y Alergia, Departamento de Análisis Clínicos y Estudios Especiales, Instituto Nacional de Pediatría, Mexico City, Mexico

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Cristina Fernandez-Mejia Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, Mexico

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Correspondence should be addressed to C Fernandez-Mejia: crisfern@biomedicas.unam.mx
DOI:
https://doi.org/10.1530/JOE-20-0184
Volume/Issue:
Volume 248: Issue 1
Article Type:
Research Article
Page Range:
1–15
Online Publication Date:
Jan 2021
Copyright:
© 2021 Society for Endocrinology 2021
Restricted access
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Pancreatic islets adapt to metabolic requirements and the hormonal milieu by modifying their size and hormone secretions. Maternal glucose demands and hormonal changes occur after weaning, to rapidly re-establish bone mineralization. Minimal information exists about glucose metabolism and pancreatic islets after lactation. This study investigated islet morphology and glucose homeostasis for 14 days after lactation in C57BL/6NHHsd mice. Compared to the day of weaning, rapid increases in the islets’ area and number of beta cells were found from the first day post-lactation, attaining maximum values on the third day post-weaning. These changes were accompanied by modifications in glucose-induced insulin secretion, glucose tolerance and insulin sensitivity. Islet-cell proliferation was already augmented before lactation ceased. Serum undercarboxylated osteocalcin concentrations increased significantly post-lactation; however, it is unlikely that this enhancement participates in earlier cell proliferation augmentation or in decreasing insulin sensitivity. Islet serotonin content was barely expressed, and serum calcium concentrations decreased. By the 14th day post-weaning, islets’ area and glucose homeostasis returned to age-matched virgin mice levels. These findings recognize for the first time that increases in islet area and insulin secretion occur during physiological post-weaning conditions. These results open up new opportunities to identify molecules and mechanisms participating in these processes, which will help in developing strategies to combat diabetes.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© 2021 Society for Endocrinology 2021
Page(s):
15
Article Type:
Research Article
Received Date:
07 Oct 2020
Accepted Date:
13 Oct 2020
Print Publication Date:
01 Jan 2021
Online Publication Date:
Jan 2021
Keywords:
insulin secretion; post-weaning; glucose tolerance; undercarboxylated osteocalcin

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