Soy isoflavones recover pancreatic islet function and prevent metabolic dysfunction in male rats

in Journal of Endocrinology
Authors:
Tatiane Aparecida Ribeiro Department of Biochemistry and Biomedical Science, McMaster University, Hamilton Ontario, Canada
Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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https://orcid.org/0000-0001-5687-1110
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Audrei Pavanello Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Laize Peron Tófolo Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Júlio Cezar de Oliveira Institute of Health Sciences, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil

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Ana Maria Praxedes de Moraes Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Claudinéia Conationi da Silva Franco Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Kelly Valério Prates Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Isabela Peixoto Martins Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Kesia Palma-Rigo Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Rosana Torrezan Department of Physiologic Science, State University of Maringá – Maringá, Parana, Brazil

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Erica Yeo Department of Biochemistry and Biomedical Science, McMaster University, Hamilton Ontario, Canada

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Rodrigo Mello Gomes Laboratory of Neuroscience and Cardiovascular Physiology, Department of Physiological Sciences, Federal University of Goiás, Goiânia, Brazil

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Flávio Andrade Francisco Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Paulo Cezar de Freitas Mathias Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Ananda Malta Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, Maringá, Parana, Brazil

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Correspondence should be addressed to A Malta: nandamalt@hotmail.com
DOI:
https://doi.org/10.1530/JOE-21-0019
Volume/Issue:
Volume 250: Issue 3
Article Type:
Research Article
Page Range:
81–91
Online Publication Date:
07 Jul 2021
Copyright:
© Society for Endocrinology 2021
Restricted access
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We tested whether chronic supplementation with soy isoflavones could modulate insulin secretion levels and subsequent recovery of pancreatic islet function as well as prevent metabolic dysfunction induced by early overfeeding in adult male rats. Wistar rats raised in small litters (SL, three pups/dam) and normal litters (NL, nine pups/dam) were used as models of early overfeeding and normal feeding, respectively. At 30 to 90 days old, animals in the SL and NL groups received either soy isoflavones extract (ISO) or water (W) gavage serving as controls. At 90 days old, body weight, visceral fat deposits, glycemia, insulinemia were evaluated. Glucose-insulin homeostasis and pancreatic-islet insulinotropic response were also determined. The early life overnutrition induced by small litter displayed metabolic dysfunction, glucose, and insulin homeostasis disruption in adult rats. However, adult SL rats treated with soy isoflavones showed improvement in glucose tolerance, insulin sensitivity, insulinemia, fat tissue accretion, and body weight gain, compared with the SL-W group. Pancreatic-islet response to cholinergic, adrenergic, and glucose stimuli was improved in both isoflavone-treated groups. In addition, different isoflavone concentrations increased glucose-stimulated insulin secretion in islets of all groups with higher magnitude in both NL and SL isoflavone-treated groups. These results indicate that long-term treatment with soy isoflavones inhibits early overfeeding-induced metabolic dysfunction in adult rats and modulated the process of insulin secretion in pancreatic islets.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© Society for Endocrinology 2021
Page(s):
11
Article Type:
Research Article
Received Date:
25 May 2021
Accepted Date:
04 Jun 2021
Print Publication Date:
01 Sep 2021
Online Publication Date:
07 Jul 2021
Keywords:
isoflavones; early overnutrition; insulin secretion; autonomic nervous system; DOHaD

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