Long-term melatonin treatment attenuates body weight gain with aging in female mice

in Journal of Endocrinology
Authors:
Isao Tamura Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Hiroshi Tamura Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Mai Kawamoto-Jozaki Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yumiko Doi-Tanaka Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Haruka Takagi Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yuichiro Shirafuta Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Yumiko Mihara Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Ryo Maekawa Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Toshiaki Taketani Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Shun Sato Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Norihiro Sugino Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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Correspondence should be addressed to H Tamura: hitamura@yamaguchi-u.ac.jp
DOI:
https://doi.org/10.1530/JOE-20-0462
Volume/Issue:
Volume 251: Issue 1
Article Type:
Research Article
Page Range:
15–25
Online Publication Date:
22 Jul 2021
Copyright:
© Society for Endocrinology 2021
Restricted access
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Women usually experience body weight gain with aging, which can put them at risk for many chronic diseases. Previous studies indicated that melatonin treatment attenuates body weight gain and abdominal fat deposition in several male animals. However, it is unclear whether melatonin affects female animals in the same way. This study investigated whether long-term melatonin treatment can attenuate body weight gain with aging and, if it does, what the mechanism is. Ten-week-old female ICR mice were given melatonin-containing water (100 μg/mL) or only water until 43 weeks. Melatonin treatment significantly attenuated body weight gain at 23 weeks (control; 57.2 ± 2.0 g vs melatonin; 44.4 ± 3.1 g), 33 weeks (control; 65.4 ± 2.6 g vs melatonin; 52.2 ± 4.2 g) and 43 weeks (control; 66.1 ± 3.2 g vs melatonin; 54.4 ± 2.5 g) without decreasing the amount of food intake. Micro-CT analyses showed that melatonin significantly decreased the deposition of visceral and s.c. fat. These results suggested that melatonin attenuates body weight gain by inhibiting abdominal fat deposition. Metabolome analysis of the liver revealed that melatonin treatment induced a drastic change in the metabolome with the downregulation of 149 metabolites, including the metabolites of glucose and amino acids. Citrate, which serves as a source of de novo lipogenesis, was one of the downregulated metabolites. These results show that long-term melatonin treatment induces drastic changes in metabolism and attenuates body weight gain and fat deposition with aging in female mice.

Supplementary Materials

    • Supplemental Figure 1. Pathway map of nucleotide synthesis. Expression levels of control group (blue) and melatonin group (red) are expressed as mean ± SD. * p<0.05, ** p<0.01 vs. control; N.D., not detected.
    • Supplemental table 1. List of down- and up-regulated metabolites in liver by long-term melatonin treatment.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© Society for Endocrinology 2021
Page(s):
11
Article Type:
Research Article
Received Date:
28 Apr 2021
Accepted Date:
16 Jun 2021
Print Publication Date:
01 Oct 2021
Online Publication Date:
22 Jul 2021
Keywords:
melatonin; female mice; obesity; body weight

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