Effect of nighttime light exposure on glucose metabolism in protein-restricted mice

in Journal of Endocrinology
Authors:
Patricia Cristine Borck Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil

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Sarah Rickli Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil

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Jean Franciesco Vettorazzi Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil
Union Education of Cascavel, UNIVEL, Cascavel, Paraná, Brazil

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Thiago Martins Batista Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil

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Antonio Carlos Boschero Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil

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Elaine Vieira Postgraduate Program on Physical Education, Universidade Católica de Brasília-UCB, Distrito Federal, Brazil

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Everardo Magalhães Carneiro Department of Structural and Functional Biology, Institute of Biology, University of Campinas/UNICAMP, Campinas, São Paulo, Brazil

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Correspondence should be addressed to P C Borck or E Vieira: pati.0816@gmail.com or elaine.vieira@ucb.br
DOI:
https://doi.org/10.1530/JOE-21-0133
Volume/Issue:
Volume 252: Issue 2
Article Type:
Research Article
Page Range:
143–154
Online Publication Date:
14 Dec 2021
Copyright:
© Society for Endocrinology 2021
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Disruption of biological rhythms due to exposure to artificial light at night (ALAN) has emerged as a new risk factor for metabolic diseases. However, the effects of ALAN exposure on energy metabolism with concomitant misalignment in the circadian system caused by nutritional imbalance remain largely unexplored. Here, we evaluate whether a low-protein (LP) diet could enhance the effects induced by exposure to ALAN on the energy metabolism and consequently predispose to metabolic disorders. Male C57BL6/J mice were weaned on a normal protein (NP) or a LP diet and housed on 12 h light:12 h darkness (LD) cycle. After 6 weeks, mice maintained on their respective diets were subdivided into normal light/darkness cycle (NP/LD; LP/LD) or exposed to ALAN (NP/LL; LP/LL) for 8 weeks. We observed that exposure to ALAN concomitant to LP diet disrupts the behavioral rhythms, without shifting the timing of food intake. Furthermore, exposure to ALAN leads to increased body and fat pad weights, higher levels of fast and fed glycemia and glucose intolerance independent of the diet consumed. Importantly, the effects of ALAN on circadian regulation of insulin sensitivity were diet-dependent with LP/LL mice showing insulin resistance in an opposite time of day than NP/LL. At the molecular level, exposure to ALAN concurrent with LP diet increased the expression of phosphoenolpyruvate carboxykinase 1 in both periods analyzed and inverted the pattern of fibroblast growth factor 21 (Fgf21) expression in the liver. Our data suggest that dietary protein restriction modulates the effects induced by nighttime light exposure on glucose metabolism, which could be partially related with the dysregulation of hepatic Fgf21 expression.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© Society for Endocrinology 2021
Page(s):
12
Article Type:
Research Article
Received Date:
07 Oct 2021
Accepted Date:
13 Oct 2021
Print Publication Date:
01 Feb 2022
Online Publication Date:
14 Dec 2021
Keywords:
artificial light at night; Fgf21; glucose metabolism; protein restriction

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