When patients with the Stein—Leventhal syndrome are treated with dexamethasone they show an increase in the excretion of oestriol (Crooke, Butt, Palmer, Morris, Edwards, Taylor & Short, 1963). It was suggested that this might be the result of an increase in the secretion of gonadotrophin since, working in this laboratory, P. S. Brown (1956) had shown that the excretion of follicle-stimulating hormone (FSH) may rise when patients are treated with cortisone.
In the present investigation eight patients with Stein—Leventhal syndrome were given dexamethasone 3 mg. daily for 5 days and their urine was collected in 24 hr. lots for 2 days before and for 6 days after starting treatment. The specimens were then
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