FSH, bone, belly and brain

in Journal of Endocrinology
Authors:
Se-Min Kim The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Farhath Sultana The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Steven Sims The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Judit Gimenez-Roig The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Victoria Laurencin The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anusha Pallapati The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Satish Rojekar The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tal Frolinger The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Weibin Zhou The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anisa Gumerova The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anne Macdonald The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Vitaly Ryu The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Daria Lizneva The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Funda Korkmaz The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tony Yuen The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Mone Zaidi The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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https://orcid.org/0000-0001-5911-9522

Correspondence should be addressed to M Zaidi: mone.zaidi@mssm.edu
DOI:
https://doi.org/10.1530/JOE-23-0377
Volume/Issue:
Volume 262: Issue 1
Article Type:
Review Article
Article ID:
e230377
Online Publication Date:
16 May 2024
Copyright:
© the author(s) 2024
Restricted access
Rent on DeepDyve

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The pituitary gland orchestrates multiple endocrine organs by secreting tropic hormones, and therefore plays a significant role in a myriad of physiological processes, including skeletal modeling and remodeling, fat and glucose metabolism, and cognition. Expression of receptors for each pituitary hormone and the hormone itself in the skeleton, fat, immune cells, and the brain suggest that their role is much broader than the traditionally attributed functions. FSH, believed solely to regulate gonadal function is also involved in fat and bone metabolism, as well as in cognition. Our emerging understanding of nonreproductive functions of FSH, thus, opens potential therapeutic opportunities to address detrimental health consequences during and after menopause, namely, osteoporosis, obesity, and dementia. In this review, we outline current understanding of the cross-talk between the pituitary, bone, adipose tissue, and brain through FSH. Preclinical evidence from genetic and pharmacologic interventions in rodent models, and human data from population-based observations, genetic studies, and a small number of interventional studies provide compelling evidence for independent functions of FSH in bone loss, fat gain, and congnitive impairment.

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Sept 2018 onwards Past Year Past 30 Days
Full Text Views 299 299 12
PDF Downloads 400 400 15

 

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© the author(s) 2024
Article ID:
e230377
Article Type:
Review Article
Received Date:
29 Nov 2023
Accepted Date:
03 Apr 2024
Print Publication Date:
01 Jul 2024
Online Publication Date:
16 May 2024
Keywords:
pituitary; FSH; bone; fat; brain

  • Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, et al.2003 TSH is a negative regulator of skeletal remodeling. Cell 115 151–162. (https://doi.org/10.1016/s0092-8674(0300771-2)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Abildgaard J, Ploug T, Al-Saoudi E, Wagner T, Thomsen C, Ewertsen C, Bzorek M, Pedersen BK, Pedersen AT & & Lindegaard B 2021 Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass. Scientific Reports 11 14750. (https://doi.org/10.1038/s41598-021-94189-2)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Adami S, Bianchi G, Brandi ML, Giannini S, Ortolani S, Dimunno O, Frediani B, Rossini M & BONTURNO study group 2008 Determinants of bone turnover markers in healthy premenopausal women. Calcified Tissue International 82 341–347. (https://doi.org/10.1007/s00223-008-9126-5)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Albertsen PC, Klotz L, Tombal B, Grady J, Olesen TK & & Nilsson J 2014 Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist. European Urology 65 565–573. (https://doi.org/10.1016/j.eururo.2013.10.032)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Asthana S, Baker LD, Craft S, Stanczyk FZ, Veith RC, Raskind MA & & Plymate SR 2001 High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology 57 605–612. (https://doi.org/10.1212/wnl.57.4.605)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Ben-Josef E, Yang SY, Ji TH, Bidart JM, Garde SV, Chopra DP, Porter AT & & Tang DG 1999 Hormone-refractory prostate cancer cells express functional follicle-stimulating hormone receptor (FSHR). Journal of Urology 161 970–976. (https://doi.org/10.1016/S0022-5347(0161831-7)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Bergamini M, Volta AD, Palumbo C, Zamboni S, Triggiani L, Zamparini M, Rinaudo L, Di Meo N, Zaramella I, Bresciani R, et al.2024 Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: the BLADE study. eLife 13 e92655. (https://doi.org/10.7554/eLife.92655)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Bogerd J, Granneman JC, Schulz RW & & Vischer HF 2005 Fish FSH receptors bind LH: how to make the human FSH receptor to be more fishy? General and Comparative Endocrinology 142 34–43. (https://doi.org/10.1016/j.ygcen.2004.12.008)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Bordoloi D, Bhojnagarwala PS, Perales-Puchalt A, Kulkarni AJ, Zhu X, Liaw K, O’connell RP, Park DH, Kulp DW, Zhang R, et al.2022 A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy. JCI Insight 7 e162553. (https://doi.org/10.1172/jci.insight.162553)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Borrelli L, De Stasio R, Parisi E & & Filosa S 2002 Relationship between adenylate cyclase sensitivity to follitropin and FSH receptor mRNA expression in the ovary of the lizard Podarcis sicula. Molecular Reproduction and Development 62 210–215. (https://doi.org/10.1002/mrd.10090)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Bowen RL, Isley JP & & Atkinson RL 2000 An association of elevated serum gonadotropin concentrations and Alzheimer disease? Journal of Neuroendocrinology 12 351–354. (https://doi.org/10.1046/j.1365-2826.2000.00461.x)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Brookmeyer R, Gray S & & Kawas C 1998 Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset. American Journal of Public Health 88 1337–1342. (https://doi.org/10.2105/ajph.88.9.1337)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cannon JG, Cortez-Cooper M, Meaders E, Stallings J, Haddow S, Kraj B, Sloan G & & Mulloy A 2010 Follicle-stimulating hormone, interleukin-1, and bone density in adult women. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 298 R790–R798. (https://doi.org/10.1152/ajpregu.00728.2009)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cannon JG, Kraj B & & Sloan G 2011 Follicle-stimulating hormone promotes RANK expression on human monocytes. Cytokine 53 141–144. (https://doi.org/10.1016/j.cyto.2010.11.011)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng YH & & Cypess AM 2021 beta3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis. JCI Insight 6 e139160. (https://doi.org/10.1172/jci.insight.139160)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cheng Y, Zhu H, Ren J, Wu H-Y, Yu J-E, Jin L-Y, Pang H-Y, Pan H-T, Luo S-S, Yan J, et al.2023 Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets. Nature Communications 14 6991. (https://doi.org/10.1038/s41467-023-42801-6)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cheung E, Tsang S, Bow C, Soong C, Yeung S, Loong C, Cheung CL, Kan A, Lo S, Tam S, et al. 2011 Bone loss during menopausal transition among southern Chinese women. Maturitas 69 50–56. (https://doi.org/10.1016/j.maturitas.2011.01.010)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Corbo RM, Gambina G, Broggio E & & Scacchi R 2011 Influence of variation in the follicle-stimulating hormone receptor gene (FSHR) and age at menopause on the development of Alzheimer’s disease in women. Dementia and Geriatric Cognitive Disorders 32 63–69. (https://doi.org/10.1159/000330472)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Crawford ED, Schally AV, Pinthus JH, Block NL, Rick FG, Garnick MB, Eckel RH, Keane TE, Shore ND, Dahdal DN, et al.2017 The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy. Urologic Oncology 35 183–191. (https://doi.org/10.1016/j.urolonc.2017.01.025)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Cui H, Zhao G, Liu R, Zheng M, Chen J & & Wen J 2012 FSH stimulates lipid biosynthesis in chicken adipose tissue by upregulating the expression of its receptor FSHR. Journal of Lipid Research 53 909–917. (https://doi.org/10.1194/jlr.M025403)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Daniel JM, Sulzer JK & & Hulst JL 2006 Estrogen increases the sensitivity of ovariectomized rats to the disruptive effects produced by antagonism of D2 but not D1 dopamine receptors during performance of a response learning task. Hormones and Behavior 49 38–44. (https://doi.org/10.1016/j.yhbeh.2005.05.001)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Devleta B, Adem B & & Senada S 2004 Hypergonadotropic amenorrhea and bone density: new approach to an old problem. Journal of Bone and Mineral Metabolism 22 360–364. (https://doi.org/10.1007/s00774-004-0495-1)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuning-Scherer J & & Gulanski B 1997 The Alzheimer’s Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer’s disease trials. Neurology 48 1511–1517. (https://doi.org/10.1212/wnl.48.6.1511)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • El Khoudary SR, Santoro N, Chen HY, Tepper PG, Brooks MM, Thurston RC, Janssen I, Harlow SD, Barinas-Mitchell E, Selzer F, et al.2016 Trajectories of estradiol and follicle-stimulating hormone over the menopause transition and early markers of atherosclerosis after menopause. European Journal of Preventive Cardiology 23 694–703. (https://doi.org/10.1177/2047487315607044)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Engler-Chiurazzi EB, Brown CM, Povroznik JM & & Simpkins JW 2017 Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury. Progress in Neurobiology 157 188–211. (https://doi.org/10.1016/j.pneurobio.2015.12.008)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Epperson CN, Sammel MD & & Freeman EW 2013 Menopause effects on verbal memory: findings from a longitudinal community cohort. Journal of Clinical Endocrinology and Metabolism 98 3829–3838. (https://doi.org/10.1210/jc.2013-1808)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, Hsia J, Margolis KL, Hogan PE, Wallace R, et al.2004 Conjugated equine estrogens and global cognitive function in postmenopausal women: Women’s Health Initiative Memory Study. JAMA 291 2959–2968. (https://doi.org/10.1001/jama.291.24.2959)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N & & Van Duijn CM 1997 Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer disease meta analysis consortium. JAMA 278 1349–1356.

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Feng Y, Zhu S, Antaris AL, Chen H, Xiao Y, Lu X, Jiang L, Diao S, Yu K, Wang Y, et al.2017 Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore. Chemical Science 8 3703–3711. (https://doi.org/10.1039/c6sc04897h)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Fisher DW, Bennett DA & & Dong H 2018 Sexual dimorphism in predisposition to Alzheimer’s disease. Neurobiology of Aging 70 308–324. (https://doi.org/10.1016/j.neurobiolaging.2018.04.004)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gallagher CM, Moonga BS & & Kovach JS 2010 Cadmium, follicle-stimulating hormone, and effects on bone in women age 42–60 years, NHANES III. Environmental Research 110 105–111. (https://doi.org/10.1016/j.envres.2009.09.012)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gemzell CA, Diczfalusy E & & Tillinger G 1958 Clinical effect of human pituitary follicle-stimulating hormone (FSH). Journal of Clinical Endocrinology and Metabolism 18 1333–1348. (https://doi.org/10.1210/jcem-18-12-1333)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gera S, Sant D, Haider S, Korkmaz F, Kuo TC, Mathew M, Perez-Pena H, Xie H, Chen H, Batista R, et al.2020 First-in-class humanized FSH blocking antibody targets bone and fat. PNAS 117 28971–28979. (https://doi.org/10.1073/pnas.2014588117)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gera S, Kuo TC, Gumerova AA, Korkmaz F, Sant D, Demambro V, Sudha K, Padilla A, Prevot G, Munitz J, et al.2022 FSH-blocking therapeutic for osteoporosis. eLife 11 e78022. (https://doi.org/10.7554/eLife.78022)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gertz ER, Silverman NE, Wise KS, Hanson KB, Alekel DL, Stewart JW, Perry CD, Bhupathiraju SN, Kohut ML & & Van Loan MD 2010 Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: a 1-year investigation. Journal of Clinical Densitometry 13 277–282. (https://doi.org/10.1016/j.jocd.2010.04.003)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Gibbs RB & & Gabor R 2003 Estrogen and cognition: applying preclinical findings to clinical perspectives. Journal of Neuroscience Research 74 637–643. (https://doi.org/10.1002/jnr.10811)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Greendale GA, Huang MH, Wight RG, Seeman T, Luetters C, Avis NE, Johnston J & & Karlamangla AS 2009 Effects of the menopause transition and hormone use on cognitive performance in midlife women. Neurology 72 1850–1857. (https://doi.org/10.1212/WNL.0b013e3181a71193)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Greendale GA, Karlamangla AS & & Maki PM 2020 The menopause transition and cognition. JAMA 323 1495–1496. (https://doi.org/10.1001/jama.2020.1757)

  • Guo Y, Zhao M, Bo T, MA, Ma S, Yuan Z, Chen W, He Z, Hou X, Liu J, Zhang Z, et al.2019 Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol. Cell Research 29 151–166. (https://doi.org/10.1038/s41422-018-0123-6)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Han X, Guan Z, Xu M, Zhang Y, Yao H, Meng F, Zhuo Y, Yu G, Cao X, Du X, et al.2020 A novel follicle-stimulating hormone vaccine for controlling fat accumulation. Theriogenology 148 103–111. (https://doi.org/10.1016/j.theriogenology.2020.03.005)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Han X, Meng F, Cao X, Du X, Bu G, Kong F, Huang A & & Zeng X 2021 FSH promotes fat accumulation by activating PPARgamma signaling in surgically castrated, but not immunocastrated, male pigs. Theriogenology 160 10–17. (https://doi.org/10.1016/j.theriogenology.2020.10.029)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Han JL, Song YX, Yao WJ, Zhou J, Du Y & & Xu T 2023 Follicle-stimulating hormone provokes macrophages to secrete IL-1beta contributing to atherosclerosis progression. Journal of Immunology 210 25–32. (https://doi.org/10.4049/jimmunol.2200475)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Hao J, Rapp PR, Janssen WG, Lou W, Lasley BL, Hof PR & & Morrison JH 2007 Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex. PNAS 104 11465–11470. (https://doi.org/10.1073/pnas.0704757104)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, Mccleary CA, Klein RA, Hake AM & & Farlow MR 2000 Estrogen for Alzheimer’s disease in women: randomized, double-blind, placebo-controlled trial. Neurology 54 295–301. (https://doi.org/10.1212/wnl.54.2.295)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Henderson VW 2006 Estrogen-containing hormone therapy and Alzheimer’s disease risk: understanding discrepant inferences from observational and experimental research. Neuroscience 138 1031–1039. (https://doi.org/10.1016/j.neuroscience.2005.06.017)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Iqbal J, Sun L, Kumar TR, Blair HC & & Zaidi M 2006 Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. PNAS 103 14925–14930. (https://doi.org/10.1073/pnas.0606805103)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Ji Y, Liu P, Yuen T, Haider S, He J, Romero R, Chen H, Bloch M, Kim SM, Lizneva D, et al.2018 Epitope-specific monoclonal antibodies to FSHbeta increase bone mass. PNAS 115 2192–2197. (https://doi.org/10.1073/pnas.1718144115)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Kleinau G & & Krause G 2009 Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocrine Reviews 30 133–151. (https://doi.org/10.1210/er.2008-0044)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Kobayashi T & & Andersen Ø 2008 The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus), 1: Isolation of multiple transcripts encoding full-length and truncated variants of FSH-R. General and Comparative Endocrinology 156 584–594. (https://doi.org/10.1016/j.ygcen.2008.02.008)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Kobayashi T, Pakarinen P, Torgersen J, Huhtaniemi I & & Andersen Ø 2008 The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus)—2. Differential follicle expression and asynchronous oogenesis. General and Comparative Endocrinology 156 595–602. (https://doi.org/10.1016/j.ygcen.2008.02.010)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Koran MEI, Wagener M, Hohman TJ & Alzheimer ’ s Neuroimaging Initiative 2017 Sex differences in the association between AD biomarkers and cognitive decline. Brain Imaging and Behavior 11 205–213. (https://doi.org/10.1007/s11682-016-9523-8)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Kumar RS, Ijiri S, Kight K, Swanson P, Dittman A, Alok D, Zohar Y & & Trant JM 2000 Cloning and functional expression of a thyrotropin receptor from the gonads of a vertebrate (bony fish): potential thyroid-independent role for thyrotropin in reproduction. Molecular and Cellular Endocrinology 167 1–9. (https://doi.org/10.1016/s0303-7207(0000304-x)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • La Marca A, Carducci Artenisio A, Stabile G, Rivasi F & & Volpe A 2005 Evidence for cycle-dependent expression of follicle-stimulating hormone receptor in human endometrium. Gynecological Endocrinology 21 303–306. (https://doi.org/10.1080/09513590500402756)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Lacreuse A & & Herndon JG 2003 Estradiol selectively affects processing of conspecifics’ faces in female rhesus monkeys. Psychoneuroendocrinology 28 885–905. (https://doi.org/10.1016/s0306-4530(0200104-x)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Lan YL, Zhao J & & Li S 2015 Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer’s disease. Journal of Alzheimer’s Disease 43 1137–1148. (https://doi.org/10.3233/JAD-141875)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Laws KR, Irvine K & & Gale TM 2016 Sex differences in cognitive impairment in Alzheimer’s disease. World Journal of Psychiatry 6 54–65. (https://doi.org/10.5498/wjp.v6.i1.54)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Lenhard M, Lennerova T, Ditsch N, Kahlert S, Friese K, Mayr D & & Jeschke U 2011 Opposed roles of follicle-stimulating hormone and luteinizing hormone receptors in ovarian cancer survival. Histopathology 58 990–994. (https://doi.org/10.1111/j.1365-2559.2011.03848.x)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Li CH, Simpson ME & & Evans HM 1949 Isolation of pituitary follicle-stimulating hormone (FSH). Science 109 445–446. (https://doi.org/10.1126/science.109.2835.445)

  • Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, Yan Q, Xu X, Cui Y, Gu Z, et al.2017 Follicular stimulating hormone accelerates atherogenesis by increasing endothelial VCAM-1 expression. Theranostics 7 4671–4688. (https://doi.org/10.7150/thno.21216)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Li Y, Li S, Xu S, Yu H, Tang L, Liu X, Wang X, Zhang Y, Zhang K, Mi S, et al.2020 Association of androgens and gonadotropins with amnestic mild cognitive impairment and probable Alzheimer’s disease in Chinese elderly men. Journal of Alzheimer’s Disease 78 277–290. (https://doi.org/10.3233/JAD-200233)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Liu S, Cheng Y, Fan M, Chen D & & Bian Z 2010a FSH aggravates periodontitis-related bone loss in ovariectomized rats. Journal of Dental Research 89 366–371. (https://doi.org/10.1177/0022034509358822)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Liu S, Cheng Y, Xu W & & Bian Z 2010b Protective effects of follicle-stimulating hormone inhibitor on alveolar bone loss resulting from experimental periapical lesions in ovariectomized rats. Journal of Endodontics 36 658–663. (https://doi.org/10.1016/j.joen.2010.01.011)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Liu XM, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, et al.2015 FSH regulates fat accumulation and redistribution in aging through the Galphai/Ca(2+)/CREB pathway. Aging Cell 14 409–420. (https://doi.org/10.1111/acel.12331)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Liu P, Ji Y, Yuen T, Rendina-Ruedy E, Demambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, et al.2017 Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature 546 107–112. (https://doi.org/10.1038/nature22342)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Lizneva D, Rahimova A, Kim SM, Atabiekov I, Javaid S, Alamoush B, Taneja C, Khan A, Sun L, Azziz R, et al.2019 FSH beyond fertility. Frontiers in Endocrinology (Lausanne) 10 136. (https://doi.org/10.3389/fendo.2019.00136)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Mariani S, Salvatori L, Basciani S, Arizzi M, Franco G, Petrangeli E, Spera G & & Gnessi L 2006 Expression and cellular localization of follicle-stimulating hormone receptor in normal human prostate, benign prostatic hyperplasia and prostate cancer. Journal of Urology 175 2072–2077. (https://doi.org/10.1016/S0022-5347(0600273-4)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Mendoza N, Quereda F, Presa J, Salamanca A, Sanchez-Borrego R, Vazquez F & & Martinez Astorquiza T 2012 Estrogen-related genes and postmenopausal osteoporosis risk. Climacteric 15 587–593. (https://doi.org/10.3109/13697137.2012.656160)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Mulnard RA, Cotman CW, Kawas C, Van Dyck CH, Sano M, Doody R, Koss E, Pfeiffer E, Jin S, Gamst A, et al.2000 Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer’s disease cooperative study. JAMA 283 1007–1015. (https://doi.org/10.1001/jama.283.8.1007)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Munir JA, Wu H, Bauer K, Bindeman J, Byrd C, Feuerstein IM, Villines TC & & Taylor AJ 2012 The perimenopausal atherosclerosis transition: relationships between calcified and noncalcified coronary, aortic, and carotid atherosclerosis and risk factors and hormone levels. Menopause 19 10–15. (https://doi.org/10.1097/gme.0b013e318221bc8d)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Nenonen HA, Lindgren IA, Prahl AS, Trzybulska D, Kharraziha I, Hulten M, Giwercman YL & & Henic E 2019 The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation. Pharmacogenetics and Genomics 29 114–120. (https://doi.org/10.1097/FPC.0000000000000374)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Odell WD, Parlow AF, Cargille CM & & Ross GT 1968 Radioimmunoassay for human follicle-stimulating hormone: physiological studies. Journal of Clinical Investigation 47 2551–2562. (https://doi.org/10.1172/JCI105937)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Olejar T, Vetvicka D, Boucek J, Zabrodsky M, Benes J, Kabesova M & & Pouckova P 2020 The FSHR expression in head and neck squamous cell cancer. A pilot immunohistochemical study. Anticancer Research 40 349–356. (https://doi.org/10.21873/anticanres.13959)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Ostergren PB, Kistorp C, Fode M, Bennedbaek FN, Faber J & & Sonksen J 2019 Metabolic consequences of gonadotropin-releasing hormone agonists vs orchiectomy: a randomized clinical study. BJU International 123 602–611. (https://doi.org/10.1111/bju.14609)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Paganini-Hill A & & Henderson VW 1996 Estrogen replacement therapy and risk of Alzheimer disease. Archives of Internal Medicine 156 2213–2217.

  • Pawlikowski M, Jaranowska M, Pisarek H, Kubiak R, Fuss-Chmielewska J & & Winczyk K 2015 Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors. Archives of Medical Science 11 1314–1317. (https://doi.org/10.5114/aoms.2015.56357)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Perales-Puchalt A, Svoronos N, Rutkowski MR, Allegrezza MJ, Tesone AJ, Payne KK, Wickramasinghe J, Nguyen JM, O’brien SW, Gumireddy K, et al.2017. Follicle-stimulating hormone receptor is expressed by most ovarian cancer subtypes and is a safe and effective immunotherapeutic target. Clinical Cancer Research 23 ,441–453. (https://doi.org/10.1158/1078-0432.CCR-16-0492)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Piao J, Yin Y, Zhao Y, Han Y, Zhan H, Luo D & & Guo J 2022 Follicle-stimulating hormone accelerates atherosclerosis by activating PI3K/Akt/NF-kappaB pathway in mice with androgen deprivation. Journal of Vascular Research 59 358–368. (https://doi.org/10.1159/000527239)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Podfigurna-Stopa A, Pludowski P, Jaworski M, Lorenc R, Genazzani AR & & Meczekalski B 2012 Skeletal status and body composition in young women with functional hypothalamic amenorrhea. Gynecological Endocrinology 28 299–304. (https://doi.org/10.3109/09513590.2011.613972)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Pollycove R, Naftolin F & & Simon JA 2011 The evolutionary origin and significance of menopause. Menopause 18 336–342. (https://doi.org/10.1097/gme.0b013e3181ed957a)

  • Ponikwicka-Tyszko D, Chrusciel M, Stelmaszewska J, Bernaczyk P, Sztachelska M, Sidorkiewicz I, Doroszko M, Tomaszewski J, Tapanainen JS, Huhtaniemi I, et al.2016 Functional expression of FSH receptor in endometriotic lesions. Journal of Clinical Endocrinology and Metabolism 101 2905–2914. (https://doi.org/10.1210/jc.2016-1014)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Radu A, Pichon C, Camparo P, Antoine M, Allory Y, Couvelard A, Fromont G, Hai MT & & Ghinea N 2010 Expression of follicle-stimulating hormone receptor in tumor blood vessels. New England Journal of Medicine 363 1621–1630. (https://doi.org/10.1056/NEJMoa1001283)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Randolph JF, Sowers M, Bondarenko IV, Harlow SD, Luborsky JL & & Little RJ 2004 Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age. Journal of Clinical Endocrinology and Metabolism 89 1555–1561. (https://doi.org/10.1210/jc.2003-031183)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Rendina D, Gianfrancesco F, De Filippo G, Merlotti D, Esposito T, Mingione A, Nuti R, Strazzullo P, Mossetti G & & Gennari L 2010 FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women. European Journal of Endocrinology 163 165–172. (https://doi.org/10.1530/EJE-10-0043)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Robin B, Planeix F, Sastre-Garau X, Pichon C, Olesen TK, Gogusev J & & Ghinea N 2016 Follicle-stimulating hormone receptor expression in endometriotic lesions and the associated vasculature: an immunohistochemical study. Reproductive Sciences 23 885–891. (https://doi.org/10.1177/1933719115623647)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Robinson LJ, Tourkova I, Wang Y, Sharrow AC, Landau MS, Yaroslavskiy BB, Sun L, Zaidi M & & Blair HC 2010 FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts. Biochemical and Biophysical Research Communications 394 12–17. (https://doi.org/10.1016/j.bbrc.2010.02.112)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Rojekar S, Pallapati AR, Gimenez-Roig J, Korkmaz F, Sultana F, Sant D, Haeck CM, Macdonald A, Kim SM, Rosen CJ, et al.2023 Development and biophysical characterization of a humanized FSH-blocking monoclonal antibody therapeutic formulated at an ultra-high concentration. eLife 12 e88898. (https://doi.org/10.7554/eLife.88898)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Ryu V, Gumerova A, Korkmaz F, Kang SS, Katsel P, Miyashita S, Kannangara H, Cullen L, Chan P, Kuo T, et al.2022 Brain atlas for glycoprotein hormone receptors at single-transcript level. eLife 11 e79612. (https://doi.org/10.7554/eLife.79612)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sacchi S, Sena P, Degli Esposti C, Lui J & & La Marca A 2018 Evidence for expression and functionality of FSH and LH/hCG receptors in human endometrium. Journal of Assisted Reproduction and Genetics 35 1703–1712. (https://doi.org/10.1007/s10815-018-1248-8)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sant D, Rokekar S & & Gera S 2022 Optimizing therapeutic humanized FSH–blocking antibody formulation using protein thermal shift assay. Annals of the New York Academy of Sciences 1521 67–78. (https://doi.org/10.1111/nyas.14952)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sheng S, Liu W, Xue Y, Pan Z, Zhao L, Wang F & & Qi X 2022 Follicle-stimulating hormone promotes the development of endometrial cancer in vitro and in vivo. International Journal of Environmental Research and Public Health 19 15344. (https://doi.org/10.3390/ijerph192215344)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Short RA, Bowen RL, O’brien PC & & Graff-Radford NR 2001 Elevated gonadotropin levels in patients with Alzheimer disease. Mayo Clinic Proceedings 76 906–909. (https://doi.org/10.4065/76.9.906)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, Fillit H, Stefanick ML, Hendrix SL, Lewis CE, et al.2004 Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women’s Health Initiative Memory Study. JAMA 291 2947–2958. (https://doi.org/10.1001/jama.291.24.2947)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Simpkins JW, Perez E, Wang X, Yang S, Wen Y & & Singh M 2009 The potential for estrogens in preventing Alzheimer’s disease and vascular dementia. Therapeutic Advances in Neurological Disorders 2 31–49. (https://doi.org/10.1177/1756285608100427)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Siraj A, Desestret V, Antoine M, Fromont G, Huerre M, Sanson M, Camparo P, Pichon C, Planeix F, Gonin J, et al.2013 Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases. BMC Cancer 13 246. (https://doi.org/10.1186/1471-2407-13-246)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, et al.2016 Follicle-stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism. Journal of Clinical Endocrinology and Metabolism 101 254–263. (https://doi.org/10.1210/jc.2015-2724)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sowers MR, Greendale GA, Bondarenko I, Finkelstein JS, Cauley JA, Neer RM & & Ettinger B 2003 Endogenous hormones and bone turnover markers in pre- and perimenopausal women: SWAN. Osteoporosis International 14 191–197. (https://doi.org/10.1007/s00198-002-1329-4)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sowers M, Zheng H, Tomey K, Karvonen-Gutierrez C, Jannausch M, Li X, Yosef M & & Symons J 2007 Changes in body composition in women over six years at midlife: ovarian and chronological aging. Journal of Clinical Endocrinology and Metabolism 92 895–901. (https://doi.org/10.1210/jc.2006-1393)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Stelmaszewska J, Chrusciel M, Doroszko M, Akerfelt M, Ponikwicka-Tyszko D, Nees M, Frentsch M, Li X, Kero J, Huhtaniemi I, et al.2016 Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells. Scientific Reports 6 37095. (https://doi.org/10.1038/srep37095)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Stilley JA, Christensen DE, Dahlem KB, Guan R, Santillan DA, England SK, Al-Hendy A, Kirby PA & & Segaloff DL 2014a FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. Biology of Reproduction 91 74. (https://doi.org/10.1095/biolreprod.114.118562)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Stilley JA, Guan R, Duffy DM & & Segaloff DL 2014b Signaling through FSH receptors on human umbilical vein endothelial cells promotes angiogenesis. Journal of Clinical Endocrinology and Metabolism 99 E813–E820. (https://doi.org/10.1210/jc.2013-3186)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Stilley JA, Guan R, Santillan DA, Mitchell BF, Lamping KG & & Segaloff DL 2016 Differential regulation of human and mouse myometrial contractile activity by FSH as a function of FSH receptor density. Biology of Reproduction 95 36. (https://doi.org/10.1095/biolreprod.116.141648)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Stilley JAW & & Segaloff DL 2018 Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta. Molecular and Cellular Endocrinology 476 79–83. (https://doi.org/10.1016/j.mce.2018.04.011)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, et al.2006 FSH directly regulates bone mass. Cell 125 247–260. (https://doi.org/10.1016/j.cell.2006.01.051)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Sun L, Zhang Z, Zhu LL, Peng Y, Liu X, Li J, Agrawal M, Robinson LJ, Iqbal J, Blair HC, et al.2010 Further evidence for direct pro-resorptive actions of FSH. Biochemical and Biophysical Research Communications 394 6–11. (https://doi.org/10.1016/j.bbrc.2010.02.113)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Tan D, Zhao Y, Ma D & & Tong F 2021 Role of FSH and FSH receptor on HUVECs migration. Gene Therapy 28 155–161. (https://doi.org/10.1038/s41434-020-00195-w)

  • Tedjawirja VN, Mieremet A, Rombouts KB, Yap C, Neele AE, Northoff BH, Chen HJ, Vos M, Klaver D, Yeung KK, et al.2023 Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm. PLoS One 18 e0285607. (https://doi.org/10.1371/journal.pone.0285607)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Ubuka T, Bentley GE & & Tsutsui K 2013 Neuroendocrine regulation of gonadotropin secretion in seasonally breeding birds. Frontiers in Neuroscience 7 38. (https://doi.org/10.3389/fnins.2013.00038)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Veldhuis-Vlug AG, Woods GN, Sigurdsson S, Ewing SK, Le PT, Hue TF, Vittinghoff E, Xu K, Gudnason V, Sigurdsson G, et al.2021 Serum FSH is associated with BMD, bone marrow adiposity, and body composition in the AGES-Reykjavik study of older adults. Journal of Clinical Endocrinology and Metabolism 106 e1156–e1169. (https://doi.org/10.1210/clinem/dgaa922)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Voytko ML 2002 Estrogen and the cholinergic system modulate visuospatial attention in monkeys (Macaca fascicularis). Behavioral Neuroscience 116 187–197. (https://doi.org/10.1037//0735-7044.116.2.187)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Wang PN, Liao SQ, Liu RS, Liu CY, Chao HT, Lu SR, Yu HY, Wang SJ & & Liu HC 2000 Effects of estrogen on cognition, mood, and cerebral blood flow in AD: a controlled study. Neurology 54 2061–2066. (https://doi.org/10.1212/wnl.54.11.2061)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Wang B, Song Y, Chen Y, Wang ES, Zheng D, Qu F & & Zhou JH 2015a Correlation analysis for follicle-stimulating hormone and C-terminal cross-linked telopetides of type I collagen in menopausal transition women with osteoporosis. International Journal of Clinical and Experimental Medicine 8 2417–2422.

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Wang J, Zhang W, Yu C, Zhang X, Zhang H, Guan Q, Zhao J & & Xu J 2015b Follicle-stimulating hormone increases the risk of postmenopausal osteoporosis by stimulating osteoclast differentiation. PLoS One 10 e0134986. (https://doi.org/10.1371/journal.pone.0134986)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC & & Humphrey MB 2007 Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS One 2 e586. (https://doi.org/10.1371/journal.pone.0000586)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Wu XY, Wu XP, Xie H, Zhang H, Peng YQ, Yuan LQ, Su X, Luo XH & & Liao EY 2010 Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women. Osteoporosis International 21 275–285. (https://doi.org/10.1007/s00198-009-0943-9)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Xiong J, Kang SS, Wang Z, Liu X, Kuo TC, Korkmaz F, Padilla A, Miyashita S, Chan P, Zhang Z, et al.2022 FSH blockade improves cognition in mice with Alzheimer’s disease. Nature 603 470–476. (https://doi.org/10.1038/s41586-022-04463-0)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Xu ZR, Wang AH, Wu XP, Zhang H, Sheng ZF, Wu XY, Xie H, Luo XH & & Liao EY 2009 Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women. Clinica Chimica Acta 400 8–13. (https://doi.org/10.1016/j.cca.2008.09.027)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Zandi PP, Carlson MC, Plassman BL, Welsh-Bohmer KA, Mayer LS, Steffens DC, Breitner JC & Cache County Memory Study Investigators 2002. Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study. JAMA 288 2123–2129. (https://doi.org/10.1001/jama.288.17.2123)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, et al.2012a Blocking antibody to the beta-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis. PNAS 109 14574–14579. (https://doi.org/10.1073/pnas.1212806109)

    • PubMed
    • Search Google Scholar
    • Export Citation

  • Zhu LL, Tourkova I, Yuen T, Robinson LJ, Bian Z, Zaidi M & & Blair HC 2012b Blocking FSH action attenuates osteoclastogenesis. Biochemical and Biophysical Research Communications 422 54–58. (https://doi.org/10.1016/j.bbrc.2012.04.104)

    • PubMed
    • Search Google Scholar
    • Export Citation