Bidirectional crosstalk between bone and muscle: the role of RANKL pathway in osteosarcopenia

in Journal of Endocrinology
Authors:
Soo Yeon Jang Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

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Kyung Mook Choi Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

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https://orcid.org/0000-0001-6175-0225

Correspondence should be addressed to K Choi: medica7@korea.ac.kr

This paper forms part of a special collection Exploring Osteoporosis and Sarcopenia. The guest editor for this section was Dr Naibedya Chattopadhyay.

DOI:
https://doi.org/10.1530/JOE-24-0093
Volume/Issue:
Volume 262: Issue 3
Article Type:
Review Article
Article ID:
e240093
Online Publication Date:
18 Jul 2024
Copyright:
© the author(s) 2024
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Osteosarcopenia, which refers to the concomitant presence of osteoporosis and sarcopenia, is expected to increase in the rapidly progressive aging world, with serious clinical implications. However, the pathophysiology of osteosarcopenia has not been fully elucidated, and no optimal treatment specific to osteosarcopenia is available. The RANKL–RANK pathway is widely used as a therapeutic target for osteoporosis. Growing evidence supports the importance of the RANKL–RANK pathway, not only in bone, but also in muscle, and the therapeutic potential of targeting this pathway in muscle diseases has been noted. The muscles and bones closely communicate with each other through various secretory factors called myokines and osteokines. This review covers the roles of the RANKL–RANK pathway in the bone and muscle and their reciprocal interactions. Moreover, we will suggest future directions to move forward for the treatment of osteosarcopenia to prepare for an upcoming aging society.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© the author(s) 2024
Article ID:
e240093
Article Type:
Review Article
Received Date:
21 Mar 2024
Accepted Date:
24 Jun 2024
Print Publication Date:
01 Sep 2024
Online Publication Date:
18 Jul 2024
Keywords:
bone; crosstalk; muscle; osteosarcopenia; RANKL

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