Oncostatin M: friend or foe in PCOS pathogenesis?

in Journal of Endocrinology
Authors:
Saba Nikanfar Pôle de Recherche en Physiopathologie de la Reproduction, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

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Farnaz Oghbaei Healthy Ageing Research Center, Neyshabur University of Medical Sceieces, Neyshabur, Iran

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Hamid R Nejabati Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Reza Zarezadeh Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

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Zeinab Latifi Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran

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Sanya Hayati Laleh Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

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lida Khodavirdilou Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center (TTUHSC), Amarillo, TX, USA

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Rasa Khodavirdilou Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center (TTUHSC), Amarillo, TX, USA

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Christiani A Amorim Pôle de Recherche en Physiopathologie de la Reproduction, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

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Amir Fattahi Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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https://orcid.org/0000-0002-5712-5336

Correspondence should be addressed to A Fattahi: fattahia@tbzmed.ac.ir

*(S Nikanfar and F Oghbaei contributed equally to this work)

DOI:
https://doi.org/10.1530/JOE-24-0140
Volume/Issue:
Volume 263: Issue 3
Article Type:
Review Article
Article ID:
e240140
Online Publication Date:
18 Nov 2024
Copyright:
© the author(s) 2024
Restricted access
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Polycystic ovary syndrome (PCOS) is a primary endocrinological disorder in women of reproductive age that is characterized by androgen excess and ovulatory irregularities. This syndrome is associated with adipose tissue dysfunction, an elevated risk of insulin resistance, hyperinsulinemia, obesity, and type 2 diabetes. Adipocyte dysfunction affects the secretion of adipokines and pro-inflammatory cytokines. Nevertheless, adipose tissue is not an exclusive source of adipokines as it can also be produced locally by reproductive tissues. Although adipokines have been recognized in the development of PCOS, the role of oncostatin M (OSM), a multifaceted adipokine, remains unclear. Current evidence suggests that this cytokine is associated with key aspects of the syndrome, including obesity, insulin resistance, hyperandrogenism, and inflammation. However, the data are often contradictory, likely due to variations in study designs, methodologies, and species differences. By investigating the link between OSM and PCOS-associated issues, this review identified the potential role of this adipokine in PCOS pathogenesis. This underscores the need for further research to clarify its predominant effects and assess its relevance as a therapeutic target.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© the author(s) 2024
Article ID:
e240140
Article Type:
Review Article
Received Date:
08 May 2024
Accepted Date:
08 Oct 2024
Print Publication Date:
01 Dec 2024
Online Publication Date:
18 Nov 2024
Keywords:
insulin resistance; obesity; oncostatin M; ovarian function; PCOS

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