The interplay between ECTO and ENDO exposomes on metabolic diseases throughout lifespan: exposome loop as a new concept

in Journal of Endocrinology
Authors:
Leticia Rafael-Vázquez Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Yazmín Godínez-Solís Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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https://orcid.org/0009-0002-8996-6188
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Daniela Cortés-Gutiérrez Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Lorena López-Griego Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Esmeralda Palacios-Brito Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Brenda Méndez-García Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Andrea Díaz-Villaseñor Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico

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Correspondence should be addressed to A Díaz-Villaseñor: diaz.villasenor@iibiomedicas.unam.mx
DOI:
https://doi.org/10.1530/JOE-24-0272
Volume/Issue:
Volume 264: Issue 2
Article Type:
Review Article
Article ID:
e240272
Online Publication Date:
10 Jan 2025
Copyright:
© the author(s) 2025
Restricted access
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The exposome encompasses the total exposure an individual experiences throughout their life, comprising components influenced by the person’s genetic, epigenetic and intrinsic and age-related traits (healthy ENDO-exposome) as well as diet, environmental factors and pollutants, habits, and sociocultural and socioeconomic aspects (ECTO-exposome). These elements interact and impact the organism, potentially leading to diseases (unhealthy ENDO-exposome). Metabolic diseases and cancer are a priority for research due to their rising prevalence. Different life stages create windows of susceptibility to external exposures. The ECTO-exposome that leads to metabolic diseases and cancer can occur from pre-birth in utero to postnatal periods, including infancy, childhood, adolescence and adulthood. In addition, we propose the concept of the ‘exposome loop’, which is defined as the response of an unhealthy ENDO-exposome to the ECTO-exposome.

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© the author(s) 2025
Article ID:
e240272
Article Type:
Review Article
Received Date:
11 Sep 2024
Rev-recd:
20 Nov 2024
Accepted Date:
09 Dec 2024
Print Publication Date:
01 Feb 2025
Online Publication Date:
10 Jan 2025
Keywords:
exposome; ENDO-exposome; ECTO-exposome; metabolic diseases; cancer

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