The levels of adropin and its therapeutic potential in diabetes

in Journal of Endocrinology
Authors:
Marek Skrzypski Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland

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Tatiana Wojciechowicz Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland

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https://orcid.org/0000-0002-3651-0972
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Agnieszka Rak Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Kraków, Kraków, Poland

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https://orcid.org/0000-0002-9572-7151
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Małgorzata Krążek Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland

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Joanna Fiedorowicz Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland

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Mathias Z Strowski Department of Hepatology and Gastroenterology, Charité-University Medicine Berlin, Berlin, Germany
Medical Clinic III, Frankfurt (Oder), Germany

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Krzysztof W Nowak Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland
Faculty of Medicine and Health Sciences, University of Kalisz, Kalisz, Poland

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Correspondence should be addressed to M Skrzypski: marek.skrzypski@up.poznan.pl
DOI:
https://doi.org/10.1530/JOE-24-0117
Volume/Issue:
Volume 265: Issue 1
Article Type:
Review Article
Article ID:
e240117
Online Publication Date:
18 Feb 2025
Copyright:
© the author(s) 2025
Restricted access
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Adropin, a peptide hormone encoded by the energy homeostasis-associated gene, is expressed in various tissues, including the brain. Accumulating evidence from in vivo and in vitro studies highlights adropin's pivotal role in modulating carbohydrate and lipid metabolism. Notably, circulating adropin levels are lower in overweight and obese humans, and experimental interventions involving adropin overexpression or synthetic administration demonstrate promising outcomes in mitigating obesity-related metabolic abnormalities and preventing weight gain. This review comprehensively summarizes the current understanding of adropin's potential implications in diverse types of diabetes. Specifically, it explores adropin's utility as a biomarker for different types of diabetes and elucidates its significance as a potential predictor of diabetic adverse outcomes. Furthermore, the review delves into the beneficial effects of adropin treatment in animal models of experimentally induced diabetes, shedding light on its mechanisms of action in modulating glucose metabolism. In this comprehensive overview, we aim to provide a nuanced understanding of multifaceted role of adropin in diabetes pathogenesis and its therapeutic potential in combating this global health challenge.

Supplementary Materials

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Print ISSN:
0022-0795
Online ISSN:
1479-6805
Copyright:
© the author(s) 2025
Article ID:
e240117
Article Type:
Review Article
Received Date:
20 Apr 2024
Rev-recd:
10 Jan 2025
Accepted Date:
31 Jan 2025
Print Publication Date:
01 Apr 2025
Online Publication Date:
18 Feb 2025
Keywords:
adropin; diabetes; energy homeostasis associated gene; glucose; GPR19

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