The effect of oestrogens on the uterus of rats and mice has been evaluated in different ways, as by observing changes in uterine weight (Astwood, 1938; Lauson, Heller, Golden & Sevringhaus, 1939), number of mitoses (Tice, 1961), nuclear volumes (Gelfant & Clemmons, 1955), or the thickness of the different tissue layers (Palkovits, Palkovits & Czeizel, 1963).
Although these methods give numerical parameters for the effect of oestrogens, they are rather elaborate, and for a rapid screening of the influence of different oestrogens or anti-oestrogens on the uterus, a more simple method would be useful.
The present paper describes a morphological test of the reaction of the mouse uterus to oestrogen which is easy to perform but permits only a subjective measurement of the effect.
An injection of oestrogen into a spayed mouse initially causes water imbibition by the uterus which can be visualized histologically, if the accumulating
Journal of Endocrinology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.
The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.
More information is on the Reasons to publish page.
| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
| Full Text Views | 1 | 0 | 0 |
| PDF Downloads | 0 | 0 | 0 |
Online ISSN: 1479-6805
Print ISSN: 0022-0795
Strengthening biomedical communities
to advance science and health
CONTACT US
Bioscientifica Ltd | Starling House | 1600 Bristol Parkway North | Bristol BS34 8YU | UK
Bioscientifica Ltd | Registered in England no 3190519
