The effects of phenelzine and several of its derivatives in interrupting pregnancy, and on sexual development, were investigated in mice.
At dose levels of one-fifth LD 50 given on days 1–6 of pregnancy, phenelzine had a low but significant activity and some derivatives were more active. There was no evidence that monoamine oxidase inhibitory activity was related to the anti-fertility activity of these compounds.
The effects of two of the compounds investigated for this purpose (WL 27 and LON 41) were partially reversed by either progesterone or prolactin.
WL 27 interrupted the normal oestrous cycle, delayed the onset of oestrus in immature female mice and depressed the weights of sex organs in immature and in non-pregnant adult mice, and in immature male mice.
These effects suggest that these compounds produce a depression of pituitary gonadotrophic activity. However, the depression is not complete since WL 27 did not interrupt pseudopregnancy.
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