Lutwak-Mann (1955) and Pincus, Miyake, Merrill & Longo (1957) have shown that the carbonic anhydrase activity of the uterine endometrium in rabbits primed with oestrogen is mainly under progestin control. Since the activity increased roughly proportionally to that of proliferative development, determinations of endometrial carbonic anhydrase have been utilized as a quantitative test for progestational activity. In a previous paper (Yamashita & Kurouji, 1961 a), we suggested that certain androgens prevent the activating effect of progesterone on the endometrial carbonic anhydrase. However, Lutwak-Mann (1955) has demonstrated that methyltestosterone itself produces marked increases in the content of uterine carbonic anhydrase. The present observation was made to ascertain whether androgenic steroids affect the activity of endometrial carbonic anhydrase. The following androgens were tested: methyltestosterone, androstenedione, androstanolone, stigmasterol and β-sitosterol.
Immature albino rabbits, weighing approximately 1·5 kg., were used. Clauberg's (1930) method was modified in that the animals were primed with 5 μg.
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