α-Methylallylthiocarbamoyl-2-methyl-thiocarbamoylhydrazine (ICI 33828) is a non-steroidal inhibitor of gonadotrophin production, acting presumably on the pituitary or hypothalamus (Paget, Walpole & Richardson, 1961; Parkes 1963). We have recently examined ICI 33828 in an assay for gonadotrophin blockade based upon prevention of the compensatory hypertrophy that follows unilateral ovariectomy in rats (Peterson, Edgren & Jones, 1962, 1964).
Following methods described previously, female Charles River rats (160–180 g.) were hemicastrated on the first day of the assay; administration of the compound was begun immediately and continued daily for 14 days. At autopsy on day 15 the ovaries were removed, cleaned and weighed on a torsion balance. Selected ovaries were prepared for histological examination. Groups of oil-treated intact and operated rats controlled each experiment, and the difference in left ovary weight between these groups was employed as a criterion for evaluation of the effect of the compound. The compound was administered as a corn
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