THE POTENTIATING ACTION OF MAGNESIUM AND MANGANESE ON THE OXYTOCIC EFFECT OF SOME OXYTOCIN ANALOGUES

in Journal of Endocrinology
Author: P. J. BENTLEY
View More View Less
Restricted access

SUMMARY

Analogues of oxytocin contract the rat uterus in vitro more strongly in the presence of 0·5 mm-Mg2+ than in the absence of the ion. This effect can be referred to an increased 'affinity' of the hormone for its receptors. Neither Ca2+ (1 mm), Sr2+ (0·5 mm) nor lower concentrations of Mg2+ (0·1 mm) have this effect. Manganese mm) was more effective than Mg2+ (0·5 mm); the former potentiated the action of 3-valine oxytocin 9·9 times; that of 8-arginine oxytocin 3·3 times and that of 8-isoleucine oxytocin 1·3 times while 0·5 mm-Mg2+ potentiated the same analogues 5·7, 1·9 and 1·1 times, respectively. The results are discussed in relation to the mechanism of action of oxytocin.

 

      Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 120 63 0
Full Text Views 67 2 0
PDF Downloads 57 1 0