The hypothesis that experimental renal hypertension results from increased activity of the renin-angiotensin-aldosterone system has been tested by determining aldosterone secretion in six dogs during the rising phase of pressure in Goldblatt hypertension. Hypertension was produced by placing a Goldblatt clamp on one kidney followed by removal of the second kidney. The animals were kept on a normal diet with a constant sodium and potassium content. The mean control blood pressure was 127 ± 6 (s.e.m.) mm. Hg and the pressure in the hypertensive stage 169 ± 5 mm. Hg. Control aldosterone secretion was 29·1 ± 7·0 μg./24 hr., but fell to 8·6 ± 1·1 μg./24 hr. in the 1st week after application of the clamp during which the arterial pressure was rising to hypertensive levels. After the blood pressure had reached its maximum value, the rate of aldosterone secretion had risen slightly to 14·5 ± 2·7 μg./24 hr. These results show that the rate of aldosterone secretion is not necessarily increased during the developing phase of benign renal hypertension.
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Online ISSN: 1479-6805
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