During an investigation of the cytological changes in the adenohypophysis (pars distalis) of lactating rabbits by light and electron microscopy, it was noticed that a number of glandular cells contained very striking nuclear inclusions (Pl. 1).
Nuclear inclusions are uncommon, and their modes of origin as well as their nature in different types of cells are likely to be variable (Gabe & Arvy, 1961; Kurosomi, 1961; Moses, 1964). Serber (1961) has described large nuclear inclusions in the basiphil cells of the pituitary of the golden hamster in conditions of gonadal deficiency. Her light-microscopical observations suggest that they are invaginated areas of cytoplasm. Favard (1961) has demonstrated the formation of intranuclear granules of protein in the spermatocytes of Ascaris megalocephala which are apparently identical with the granules synthesized in the cytoplasm.
The inclusions described in this note were present in cells with abundant granular endoplasmic reticulum, but in general, relatively few
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