A case is described in which the presence of an adrenal cortical adenoma was predicted from the association of hypertension, hypokalaemia, raised aldosterone secretion and depressed plasma renin concentration.
Pre-operatively, administration of a spironolactone for a period of 10½ months corrected the electrolyte abnormalities, increased the plasma renin concentration to normal and lowered the blood pressure, although the raised aldosterone secretion was unchanged.
At operation a typical adrenal cortical adenoma was found.
Renal biopsy at operation showed arteriolar fibrinoid lesions, although no retinal lesions were seen at any stage.
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