PLASMA CONCENTRATION OF RENIN IN A PATIENT WITH CONN'S SYNDROME WITH FIBRINOID LESIONS OF THE RENAL ARTERIOLES: THE EFFECT OF TREATMENT WITH SPIRONOLACTONE

in Journal of Endocrinology
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SUMMARY

A case is described in which the presence of an adrenal cortical adenoma was predicted from the association of hypertension, hypokalaemia, raised aldosterone secretion and depressed plasma renin concentration.

Pre-operatively, administration of a spironolactone for a period of 10½ months corrected the electrolyte abnormalities, increased the plasma renin concentration to normal and lowered the blood pressure, although the raised aldosterone secretion was unchanged.

At operation a typical adrenal cortical adenoma was found.

Renal biopsy at operation showed arteriolar fibrinoid lesions, although no retinal lesions were seen at any stage.

 

Society for Endocrinology

Sept 2018 onwards Past Year Past 30 Days
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